Gamma glutamyl transferase - plasma or serum

Last updated: Monday, 06, August, 2007

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Item Process
Specimen

5 mL blood in lithium heparin or plain tube.

Method

Spectrophotometry.

Reference Interval
Male: <50 U/L
Female: <30 U/L
Application

Assessment of liver disease.

Interpretation

Increased levels are found in cholestatic liver disease and in hepatocellular disease when there is an element of cholestasis.

Levels are increased in diabetes, with chronic intake of excess alcohol and with certain drugs (especially phenytoin) as a result of enzyme induction.

Pancreatitis and prostatitis may also be associated with increased levels.

Levels may be normal early in the course of acute hepatocellular damage eg, acute viral hepatitis, paracetamol hepatotoxicity.

ReferenceRochling FA. Clin Cornerstone 2001; 3(6): 1-12.