Gastrin - serum

Last updated: Friday, 26, March, 2004

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Item Process
Specimen

5 mL blood in plain tube.

Patient must be fasting.

Serum should be separated promptly and stored frozen.

Method

Immunoassay.

Reference Interval
<100 ng/L.
ApplicationDiagnosis of Zollinger-Ellison syndrome.
Interpretation

If the patient is fasting, and is not taking therapy for peptic ulcer, an elevated level indicates abnormally increased gastrin production.

If the level is 100-500 ng/L, a stimulation test, using either secretin or intravenous calcium, may help to distinguish Zollinger-Ellison syndrome from other causes of hypergastrinaemia eg, atrophic gastritis and pernicious anaemia - consult pathologist.

ReferenceLi ML and Norton JA. Curr Treat Options Oncol 2001; 2(4): 337-346.