Parathyroid hormone-related protein (PTHrP) - plasma

Last updated: Sunday, 21, March, 2004

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Item Process
Specimen

5 mL blood in each of two special heparin/Trasylol tubes.

Contact laboratory as the specimen must be processed immediately.

Method

Immunoassay.

Reference Interval

<5 pmol/L (method dependent).

Application

To determine the cause of hypercalcaemia when malignancy is suspected but cannot be detected by other means.

Can be used as a tumour marker in some malignancies to monitor progress.

Interpretation

An elevated level in a patient with hyper­calcaemia of unknown cause suggests malignancy, especially squamous carcinoma.

Rising levels indicate progression of the tumour.

ReferenceDeftos LJ. Endocrinol Metab Clin North Am 2002; 31(1): 141-158.