Phenobarbitone - serum

Last updated: Sunday, 21, March, 2004

MBS Online Search Page: Click here for details

Item Process
Specimen

5 mL blood in plain tube.

Method

Chromatography, immunoassay.

Therapeutic Interval

65-170 µmol/L (15-40 mg/L).

Application

Therapeutic drug monitoring of phenobarbitone or primidone.

Interpretation

Phenobarbitone has a long half-life and a steady state may not be reached for several weeks.

Mean half-life is 100 hours (range 50-150 hours).

Primidone is metabolised to phenobarbitone.

ReferenceGlauser TA and Pippenger CE. Epilepsia 2000; 41(8): 6-15.