Centromere antibodies – serum
Last updated: Monday, 29, May, 2006
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5 mL blood in plain tube.
Indirect IF (part of antinuclear antibody test).
| Reference Interval|
Qualitative test. Positive is significant.
Investigation of systemic rheumatic disease.
Diagnosis of CREST syndrome.
May occasionally be associated with Primary Biliary Cirrhosis.
Moderately specific, present in 90% of patients with CREST syndrome.
Spencer-Green G et al. Am J Med 1997; 103(3): 242-248.