Porphobilinogen - urine

Last updated: Thursday, 25, March, 2004

MBS Online Search Page: Click here for details

Item Process
SpecimenRandom urine specimen, kept frozen and protect from light if immediate analysis is not possible.
Method

Spectrophotometry.

Reference Interval
<10 µmol/L.
ApplicationDiagnosis of acute neurological porphyria (acute intermittent porphyria, porphyria variegata, hereditary coproporphyria) during a symptomatic period.
Interpretation

Porphobilinogen elevation establishes the diagnosis of an acute neurological porphyria, but the pattern of increased urinary porphyrin excretion must be defined to identify the specific disorder.

During an acute episode a normal porphobilinogen excludes porphyria as the cause of the acute symptoms.

Reference

Lecha M et al. Dermatol Ther. 2003; 16(1): 65-72.