Primidone - serum

Last updated: Saturday, 20, March, 2004

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Item Process
Specimen5 mL blood in plain tube.
Method

Chromatography or immunoassay.

Therapeutic Interval

22-50 µmol/L (4.8-11.0 mg/L).

ApplicationTherapeutic drug monitoring.
InterpretationPhenobarbitone is an active metabolite of primidone and the level of phenobarbitone is often measured as well as, or instead of, primidone. Steady state level of primidone is reached after 48 hours. Mean half-life 10 hours (range 3-20 hours).
Reference

Cloyd JC et al. Clin Pharmacol Ther 1981; 29: 402-407.