Selenium - blood, plasma
Last updated: Friday, 26, March, 2004
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|Specimen||2 mL blood in lithium heparin tube.|
Atomic absorption spectrophotometry.
| Reference Interval|
There is significant variability in different countries and regions depending on dietary selenium.
Plasma: 0.75-1.35 µmol/L
Detection of selenium deficiency in patients with dietary deficiency, especially patients on a non-supplemented synthetic amino acid diet (eg, phenylketonuria, total parenteral nutrition).
Such diets are now usually supplemented with selenium. Detection of selenium toxicity.
In humans significant selenium deficiency is manifest primarily as cardiomyopathy. This correlates poorly with plasma selenium levels and rarely occurs in selenium deficient patients on total parenteral nutrition.
Keshan disease, a cardiomyopathy in the low-selenium Keshan region of
Selenium toxicity is common in herbivores in seleniferous regions, but occurs in humans only after ingestion of selenium as a chemical, rather than from a high dietary intake.
Schrauzer GN. Adv Food Nutr Res. 2003; 47: 73-112.