Trypsin - faeces

Last updated: Wednesday, 31, March, 2004

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Item Process

5 g faeces (random) frozen immediately after collection.



Some laboratories may assay chymotrypsin which requires a different substrate.

Both are being replaced by specific assays for human pancreatic elastase. 
See Pancreatic elastase - faecal.

Reference Interval

Method dependent.


Diagnosis of pancreatic exocrine failure. Assessment of pancreatic enzyme replacement.


Faecal trypsin and chymotrypsin are reduced in pancreatic exocrine failure.

Malabsorption and decreased faecal enzymes are not usually obvious until >95% of the pancreas has been destroyed.

ReferenceGowenlock AH. Ann Clin Biochem 1977; 14: 61-89.