Complement component C4 allotypes
Last updated: Wednesday, 14, April, 2004
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5 mL blood in plain tube.
Serum should be frozen at -20°.
| Reference Interval|
C4 allotyping is of limited use in the investigation of patients with autoimmune disease and persistent low or borderline C4 levels.
Null alleles at the C4 loci are associated with a number of autoimmune diseases including SLE, scleroderma and rheumatoid arthritis.
Ratnoff W et al. Rheum Dis Clin North Am 1996; 22(1): 75-94.