Glycated haemoglobin - red cell

Last updated: Friday, 04, June, 2010

The item number and fee shown are for Australia only. The fee is the Medicare Schedule Fee.

Laboratories may in some circumstances charge above this fee.

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Item Process
Specimen

5 mL blood in lithium heparin tube.

Method

Chromatography, electrophoresis, immunoassay.

Methods may be specific for HbA1c or may measure total glycohaemoglobin (HbA1).

Reference Interval

HbA1c: 3.5 - 6.0%
HbA1: 4.5 - 7.0%

Application

Diabetes mellitus: monitoring of glycaemia over previous three months.

Interpretation

The result reflects the average glucose concentration over the life of the red cells although some methods give a falsely high reading if the patient is hyperglycaemic when the blood is collected.

HbA1c levels <8% indicate good control.

Levels will be lower than appropriate for the degree of diabetic control in the presence of a reticulocytosis.

See also Fructosamine.

Reference

Krishnamurti U and Steffes MW. Clin Chem 2001; 47(7):1157-65.