Homogentisic acid - urine
Last updated: Monday, 22, March, 2004
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Qualitative colour test, colorimetry, HPLC.
| Reference Interval|
Diagnosis of alkaptonuria. Patients present with dark pigmentation of sclerae and ear cartilage, early osteoarthritis of hips (with darkly pigmented cartilage). Their urine contains a reducing substance that is not glucose and the urine characteristically darkens on standing.
An increased level is diagnostic of alkaptonuria.
Bory C et al. Clin Chim Acta 1990; 189: 7-11.