Delayed hypersensitivity skin tests

Last updated: Thursday, 15, April, 2004

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Item Process

In vivo tests.


Intradermal injections.

Antigens tested include candida, tetanus toxoid, diphtheria toxoid, proteus, tuberculin, streptokinase and trichophyton.

Reference Interval

Induration 3 mm at 48 hours is a positive reaction.


Investigation of delayed hypersensitivity (cell mediated immunity).

Assessment and follow up of patients with immunodeficiency.

Only very limited availability.


A negative reaction, in spite of previous sensitisation to the antigen(s), indicates anergy. The results are expressed as the sum of the diameters of positive reactions (numerator).
See also Tuberculin sensitivity test (Mantoux test).


Report of an IUIS Scientific Committee. Clin Exp Immunol 1999; 118(1): 1-28.