Lactate dehydrogenase (LD) - plasma or serum

Last updated: Friday, 04, June, 2010

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Item Process
Specimen

5 mL blood in lithium heparin or plain tube.

Method

Spectrophotometry.

Reference Interval
110-230 U/L (method and age dependent).
Application

Of no value in the diagnosis of myocardial infarction.

It is occasionally useful in the assessment of patients with liver disease or malignancy (especially lymphoma, seminoma, hepatic metastases); anaemia when haemolysis or ineffective erythropoiesis suspected.

Although it may be elevated in patients with skeletal muscle damage it is not a useful in this situation.

Interpretation

The ubiquitous tissue distribution of LD makes it a non-specific indicator of disease.

Increased levels are found in myocardial infarction, liver disease, haemolysis, ineffective erythropoiesis, some malignancies (especially non-Hodgkin’s lymphoma), muscle disease, and numerous other disease processes involving tissue damage.

Haemolysis during collection, delays in processing, or refrigeration of unseparated blood may cause an artefactual increase in enzyme activity. See Table 1.

Reference

McComb RB. In: Homberger HA ed. Clinical and Analytical Concepts in Enzymology. College of American Pathologists 1983.