DNA ploidy

Last updated: Wednesday, 31, March, 2004
Item Process

10 mL blood or 1-2 mL bone marrow aspirate in lithium heparin; fresh tissue.


Flow cytometry, image analysis.


To detect abnormal DNA content (aneuploidy) in neoplastic disorders.

Also useful in the diagnosis of triploidy in an aborted fetus.


Neoplastic cells may have chromosome alterations which result in an increase or decrease in the total DNA content.
These changes may be of prognostic significance, eg, in ovarian, prostatic and bladder carcinoma.

Consult pathologist.


Herrington CS and McGee JO. In: McGee JO et al eds. Oxford Textbook of Pathology. Oxford University Press 1992.