Fibrinogen - plasma

Last updated: Friday, 02, April, 2004
Item Process

4.5 mL blood in 0.5 mL citrate.


Tests based on thrombin clotting time are in common use.

Also, heat precipitation and immunoassay

Reference Interval

1.5-4.0 g/L. Some variation with method.


Investigation of possible acquired or inherited bleeding disorder.


Low levels indicate reduced production (liver disease, inherited deficiency) or increased consumption (DIC, fibrinolysis). Levels are elevated in an acute phase response.

A discrepancy between functional and immunological methods is found in the presence of FDP, and in dysfibrinogenaemia.


Exner T et al. Am J Clin Pathol 1979; 71: 521-527.