Haemoglobin M

Last updated: Wednesday, 28, April, 2004
Item Process
Specimen

5 mL blood in any anticoagulant.

Method

Spectrophotometry and electrophoresis on a lysate of washed red cells.

See Haemoglobin electrophoresisHaemoximetry and Methaemoglobin, sulphaemoglobin - blood.

Application

Investigation of chronic unesplained cyanosis.

Suspicion of hereditary methaemoglobinaemia.

Interpretation

Methaemoglobinaemia due to inerited haemoglobinopathy is defined by the presence of haemoglobin M.

Reference

Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995.

Blain B. Haemoglobinopathy Diagnosis. Blackwell Science 2001.