Cardiac (endomyocardial) biopsy

Last updated: Wednesday, 08, August, 2007
Item Process

Endomyocardial biopsies are usually taken from the right ventricle. Four to six tissue fragments should be submitted.


Specimen submitted in 10% formal saline. In acute cardiac rejection frozen section may be contemplated although rapid paraffin processing is preferable.


Assessment of allograft rejection with biopsies taken according to a standard protocol. Also utilized in diagnostic investigation of cardiomyopathy, myocarditis and cariac amyloid.


Procedure often limited to specialist centres. Consult with pathologist prior to biopsy procedure.


Silver MD, Gotlieb AI, Schoen FJ. Cardiovascular Pathology. Third Edition. Churchill Livingstone, 2001.