Histone antibodies - serum
Last updated: Monday, 22, March, 2004
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in plain tube. |
| Method | Immunoassay. |
| Application | To define specificity of ANA. Classically histone antibodies give a homogeneous pattern on indirect IF. |
| Interpretation | Histone antibodies are of limited value in distinguishing between SLE and drug-induced lupus. Although present in 100% of procainamide-induced lupus they also occur in 20% of patients with SLE. |
| Reference | Adams, B et al. Int J Dermatol 2000; 39:12 887-891. |