Immunoglobulins G, A, M - serum

Last updated: Wednesday, 17, March, 2004
Item Process
Specimen

5 mL blood in plain tube.

Method

Immunoassay.

Reference Interval

Varies with age - see Table 2.

Application

Assessment of patients with recurrent sinopulmonary infection, sepsis, gastrointestinal infection or other clinical presentations suggestive of immunoglobulin deficiency.

Electrophoresis ± immunofixation is required to exclude the presence of a paraprotein.

Detection of hypogammaglobulinaemia and monitoring immunoglobulin levels in patients with multiple myeloma or chronic lymphocytic leukaemia.

Interpretation

Normal immunoglobulin levels do not exclude humoral immunodeficiency.

Further studies, such as assessment of antibody response following administration of vaccines and/or IgG subclasses, may be required if there is a high degree of clinical suspicion.

Reference

Check IJ and Papadea C. In: Rose NR et al eds. Manual of Clinical Laboratory Immunology. 5th ed. 1998.