Enterovirus antibodies - serum

Last updated: Saturday, 03, April, 2004

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5-10 mL blood in plain tube.


Neutralisation (serotype specific), EIA.


Of limited value in the diagnosis of myocarditis, encephalitis, aseptic meningitis, pleurodynia.

Viral isolation or detection of nucleic acid after amplification (nasopharyngeal aspirate or CSF, as appropriate) is more satisfactory.

With the increasing availability of PCR very few laboratories still perform enterovirus serology.


The enterovirus group includes Coxsackieviruses A and B and echoviruses.

Antibody tresting is of very limited usefulness because of the numerous (>70) serotypes.

Occasionally useful in the diagnosis of hand-foot-mouth disease, but this is usually a clinical diagnosis.


Romero JR and Rotbart HA. In: Murray PR et al eds. Manual of Clinical Microbiology. 8th ed. ASM Press 2003.